PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 2, 2026Journal of Translational Medicine12 citationsOpen Access

IDO family: the metabolic crossroads connecting immunity, nerves and tumors

View Full Paper
XWXijie WangZCZhe ChenLCLinxi Chen

Key Points

  • To investigate the IDO family's role in various diseases via the kynurenine pathway and its potential for therapeutic targeting.
  • Review of existing literature on IDO family functions and associated diseases.
  • Analysis of the kynurenine pathway as it relates to immunity and tumors.
  • Exploration of therapeutic strategies including multi-target inhibitors and biomarker-guided precision medicine.
  • IDO family identified as a promising target for therapeutic intervention.
  • Potential for innovative delivery systems to improve treatment efficacy.
  • Insight into non-enzymatic functions and their implications for downstream signaling in diseases.

Abstract

The IDO family plays a multifaceted and context-dependent role in various diseases through the kynurenine pathway, making it a promising target for diagnostic biomarkers and therapeutic intervention. Future research should focus on optimizing multi-target inhibitors, developing innovative delivery systems, establishing biomarker-guided precision medicine strategies, and exploring non-enzymatic functions and downstream signaling networks of the IDO family. These efforts will help overcome the limitations of current therapies and provide new treatment paradigms for refractory diseases related to immune metabolic disorders.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6980fcb6c1c9540dea80e720https://doi.org/10.1186/s12967-026-07758-2
Ask AI
Helpful
Bookmark
Share
View Full Paper