Antimicrobial Resistance Pattern of Escherichia Coli (E. coli) and Klebsiella Spp Isolated from Patients with Urinary Tract Infection

Background: To better understand the frequency of E. coli and Klebsiella spp. among patients with urinary tract infections at the University of Benin Teaching Hospital, Benin City. Objective: This study aimed to analyze their patterns of antibiotic resistance. Methods: The Kirby-Bauer disk-diffusion method was employed to test the susceptibility of various microbes. Results: E. coli was the most prevalent pathogen in this study's 50 samples, with a prevalence of 64%, followed by Klebsiella spp. with a prevalence of 36%. Escherichia coli isolates were highly susceptible to imipenem (75%) and nitrofurantoin (65.6%), but showed high resistance to cefotaxime (100%), amoxicillin-clavulanate acid (100%), and nalidixic acid (96.9%). Klebsiella spp isolates were highly susceptible to Imipenem (50%) but showed 100% resistance to amoxicillin-clavulanate acid and cefotaxime, respectively. Therefore, these results should form the basis for preliminary decision-making about the best course of treatment for urinary tract infections (UTIs). Conclusion: This study demonstrated that the effectiveness of UTI therapy using available antibiotics is limited due to the increasing prevalence of antibiotic-resistant uropathogens.