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The aim is to compare the effectiveness and timing of tenecteplase and alteplase in acute ischemic stroke treatment using mobile stroke units.

February 2, 2026Stroke

Abstract WP034: Prehospital Thrombolysis on the Mobile Stroke Unit: A Comparative Analysis of Tenecteplase vs Alteplase

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The aim is to compare the effectiveness and timing of tenecteplase and alteplase in acute ischemic stroke treatment using mobile stroke units.
Conducted a single-center, retrospective review of patients treated with IV thrombolysis.
Compared outcomes and times of administration between patients receiving tenecteplase and alteplase.
Assessed MSU door-to-IVT and alarm-to-IVT times and functional stroke outcomes using NIHSS and mRS.
No significant differences in door-to-IVT times (median 21 vs 19 min) or alarm-to-IVT times (median 42 vs 39 min).
Functional outcomes were similar at hospital discharge and follow-up, except for better 30-day mRS for tenecteplase.
Rates of radiographic parenchymal hemorrhage were similar (TNK: 6.9%, tPA: 6.2%).

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This single-center study compares thrombolysis outcomes of tenecteplase and alteplase in prehospital settings, suggesting similar effectiveness.

Patel et al. (2026) studied this question.

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This single-center study compares thrombolysis outcomes of tenecteplase and alteplase in prehospital settings, suggesting similar effectiveness.