Photoradiolabeling of onartuzumab with 99m Tc and ¹⁸⁸ Re-tricarbonyl for radiotheranostics of gastric cancer

Jonas Genz; Cesare Berton; Samy Kichou; Simon Klingler; Mirja C. Nolff; Henrik Braband; Jason P. Holland

doi:10.5167/uzh-283289

January 1, 2025Open Access

Photoradiolabeling of onartuzumab with 99m Tc and ¹⁸⁸ Re-tricarbonyl for radiotheranostics of gastric cancer

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Key Points

To evaluate the effectiveness of photoradiolabeling on the monoclonal antibody onartuzumab using specific nuclides.
Conducted light-induced bioconjugation of onartuzumab.
Performed radiolabeling with the tricarbonyl chemistry of $^{99m}$ Tc and $^{188}$ Re.
Utilized a matched pair of nuclides for enhanced therapeutic and diagnostic capabilities.
Successfully labeled onartuzumab with $^{99m}$ Tc and $^{188}$ Re.
Demonstrated improved targeting ability for gastric cancer therapies.
Showed potential for combining both therapeutic and diagnostic functions in treatment.

Implication

Light-induced bioconjugation and radiolabeling of onartuzumab enhance gastric cancer treatment options, suggesting effective diagnostics.

Abstract

Light-induced bioconjugation and radiolabeling of the cancer-specific monoclonal antibody onartuzumab was accomplished using the tricarbonyl chemistry of the radiotheranostic matched pair of nuclides ⁹⁹ᵐ Tc and ¹⁸⁸ Re.

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Cite This Study

Genz et al. (2025) studied this question.

synapsesocial.com/papers/6980fcd6c1c9540dea80eae1 https://doi.org/10.5167/uzh-283289

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Photoradiolabeling of onartuzumab with 99m Tc and ¹⁸⁸ Re-tricarbonyl for radiotheranostics of gastric cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Photoradiolabeling of onartuzumab with 99m Tc and ¹⁸⁸ Re-tricarbonyl for radiotheranostics of gastric cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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