PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 2, 2026Asian Journal of Psychiatry3 citationsOpen Access

Molecular evidence associating GLP-1 receptor agonists and brain-derived neurotrophic factors in neurodegenerative and psychiatric disorders: A systematic review

View Full Paper
TXTianyi XuYZYang Jing ZhengSWSabrina Wong

Key Points

  • The aim is to explore the relationship between GLP-1 receptor agonists and BDNF in the context of neurodegenerative and psychiatric disorders.
  • Conducted a systematic review of preclinical studies
  • Analyzed the effects of GLP-1 receptor agonists on BDNF levels
  • Explored neuroprotective mechanisms associated with BDNF
  • GLP-1 receptor agonists consistently upregulate BDNF in preclinical models
  • BDNF plays a central role in mediating neuroprotection
  • Some BDNF-independent actions of GLP-1 receptor agonists were identified

Abstract

GLP-1RAs upregulate BDNF in preclinical models, supporting its role as a key mediator of neuroprotection. Despite some BDNF-independent actions, the consistent restoration of neurotrophic support positions BDNF as a central pathway for disease modification.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6980fd18c1c9540dea80ed94https://doi.org/10.1016/j.ajp.2026.104870
Ask AI
Helpful
Bookmark
Share
View Full Paper