8-Chloro-adenosine inhibits breast cancer progression by inducing ferroptosis via the ADAR1/miR-101-3p/SLC7A11 axis

Key Points

• The central aim is to understand how 8-chloro-adenosine promotes ferroptosis to inhibit breast cancer progression.
• Identified the pathway involving ADAR1/miR-101-3p/SLC7A11.
• Examined the effects of 8-chloro-adenosine on breast cancer cells.
• Utilized cellular assays to measure ferroptosis induction.
• 8-Chloro-adenosine effectively induces ferroptosis in breast cancer cells.
• Inhibition of ADAR1 leads to increased ferroptosis markers.
• Reduced expression of SLC7A11 correlates with 8-Chloro-adenosine treatment.