PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
February 2, 2026Stroke

Abstract A094: Circulating Proteins and microRNAs in E4FAD Mice and Humans as Biomarkers of Cerebral Microbleeds

View Full Paper
Ask AI
Bookmark
Share

Authors

ASAbhinav SrinathDCDiana Vera CruzRLRhonda Lightle

Discussion

Loading...

Member takes

Overview

Identifies circulating proteins and microRNAs associated with cerebral microbleeds, implying potential for early detection in at-risk populations.

Key Points

  • The aim is to assess circulating proteins and microRNAs as biomarkers for cerebral microbleeds in E4FAD mice and humans.
  • Assessed plasma miRNome in E4FAD mice and CMB patients alongside controls.
  • Identified differing expressed miRNAs linked to CMB transcriptomes using statistical analysis.
  • Quantified levels of 10 proteins associated with CMBs in CMB patients and matched controls.
  • Employed Elastic Net for feature selection and calculated sensitivity, specificity, and AUC for biomarkers.
  • Eighteen DE miRNAs were found in E4FAD mice; 31 DE miRNAs in human CMB subjects.
  • Identified significant miRNA-mRNA interactions leading to enriched pathways, indicating functional relevance.
  • Highlighted biomarkers including Aβ-40 and GFAP displayed better differential performance for CMB diagnosis (AUC=73.33%).

Cite This Study

Srinath et al. (2026) studied this question.

synapsesocial.com/papers/6980fd60c1c9540dea80f23chttps://doi.org/10.1161/str.57.suppl_1.a094
View Full Paper
Ask AI
Bookmark
Share