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February 2, 2026Cell ReportsOpen Access

HRD1 negatively regulates autolysosome formation by inhibiting liquid-liquid phase separation of SNAP29

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Authors

WQWenyan QuDCDi ChenHZHongyu Zhao

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Overview

Demonstrates HRD1's role in regulating autolysosome formation by SNAP29, suggesting a new regulatory mechanism.

Key Points

  • The study aims to explore how HRD1 influences autolysosome formation through its effect on SNAP29 and liquid-liquid phase separation.
  • Analyzed the role of HRD1 in autophagy and autolysosome formation.
  • Investigated the interaction between HRD1 and SNAP29.
  • Examined SNAP29 phase separation dynamics in vivo and in vitro.
  • HRD1 deficiency increases autophagy activity and autolysosome formation.
  • SNAP29 forms dynamic condensates essential for SNARE complex assembly.
  • HRD1 suppresses SNAP29 condensation, and its depletion accelerates SNARE assembly.

Cite This Study

Qu et al. (2026) studied this question.

synapsesocial.com/papers/6980fd60c1c9540dea80f295https://doi.org/10.1016/j.celrep.2025.116914
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