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Reveals electron attachment effects on DNA damage in 8-bromo-purine derivatives, suggesting new insights for cancer therapy.
Based on radiation chemistry, our understanding of the one-electron reduction of 8-Br-dA and 8-Br-dG has been enhanced substantially. This mechanistic background is crucial for a better understanding of and addressing their significant roles in the biological environment, such as DNA radiosensitizers for cancer radiation therapy or as biomarkers for early inflammation.
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Chryssostomos Chatgilialoglu (2026) studied this question.
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