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February 2, 2026Cellular and Molecular Gastroenterology and Hepatology0 citationsOpen Access

Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization

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KAKatherine E. AnkenbauerVanderbilt UniversityYYYilin YangVanderbilt UniversityMRMichael RendlIcahn School of Medicine at Mount Sinai

Key Points

  • This research aims to understand the role of Pcdh20 as a target gene of POU2F3 in tuft cells and its importance in microvillus structure.
  • Investigated the expression of Pcdh20 in tuft cells
  • Analyzed the microvillar structure and organization
  • Assessed the presence of mechanosensory components like TMC1
  • Pcdh20 is crucial for maintaining the structure of microvilli in tuft cells
  • Tuft cells share similar mechanosensory components as cochlear hair cells
  • Evidence suggests tuft cells might possess mechanosensory capabilities

Abstract

Pcdh20 is a POU2F3 target gene in tuft cells, critical to maintain the rigid microvillar apparatus. These findings, together with the shared expression of mechanosensory components like TMC1, support the hypothesis that tuft cells could have mechanosensory capabilities analogous to cochlear hair cells.

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Cite This Study

Ankenbauer et al. (2026) studied this question.

synapsesocial.com/papers/6980fdc7c1c9540dea80f78chttps://doi.org/10.1016/j.jcmgh.2026.101742
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