Potassium Ion Fluorescent Sensing from Chemically Stimulated Mammalian Cells Using a GINKO2-Encapsulated Sensor Fibremat

Azumi Sako; Yusuke Nasu; Akiko Obata; Toshihisa Mizuno

doi:10.1039/d5cc05871f

January 1, 2026Chemical Communications

Potassium Ion Fluorescent Sensing from Chemically Stimulated Mammalian Cells Using a GINKO2-Encapsulated Sensor Fibremat

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Key Points

This research aims to develop a platform for fluorescent sensing of potassium ions using GINKO2-encapsulated nanofibers.
Developed electrospun fibremats containing GINKO2 fluorescent sensor.
Established a method for immobilizing sensor proteins within nanofibers.
Conducted tests on potassium ion detection in stimulated mammalian cells.
Demonstrated reversible detection of potassium ions using the GINKO2 sensor.
Showed effective immobilization of sensor proteins in fibermats.
Achieved a responsive fluorescent signal upon potassium ion interaction.

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Implication

Researchers develop GINKO2-encapsulated sensor fibremats to detect potassium ions in mammalian cells, suggesting a new detection method.

Abstract

The nanofibers' interior of electrospun fibremats provides an effective platform for immobilizing sensor proteins for biomolecule detection. We developed fibremats with GINKO2-a fluorescent K⁺ sensor-encapsulated in nanofibres, enabling reversible K⁺...

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Sako et al. (2026) studied this question.

synapsesocial.com/papers/6980fe00c1c9540dea80fb3e https://doi.org/10.1039/d5cc05871f

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Potassium Ion Fluorescent Sensing from Chemically Stimulated Mammalian Cells Using a GINKO2-Encapsulated Sensor Fibremat

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Potassium Ion Fluorescent Sensing from Chemically Stimulated Mammalian Cells Using a GINKO2-Encapsulated Sensor Fibremat

Key Points

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Abstract

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