Therapeutic Update on Topical Steroid Withdrawal

Abstract: Topical steroid withdrawal syndrome (TSW) is an emerging iatrogenic condition increasingly reported in patients following prolonged topical corticosteroid use, particularly among those with atopic dermatitis (AD). Despite rising awareness, TSW remains controversial and under-recognized due to its lack of formal diagnostic criteria and overlap with poorly controlled AD. In response to the growing demand for guidance, we review a wide range of treatments currently being used or studied for TSW, including pharmacologic therapies, natural products, lifestyle interventions, and alternative approaches such as acupuncture and dietary modifications. While many strategies show benefits, few are supported by rigorous clinical evidence. This article aims to provide clinicians and patients with a reference of existing treatment options, highlight areas of uncertainty, and call for further research into validated, evidence-based therapies for this condition.