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This research aims to identify genetic associations related to cholesterol synthesis intermediates, specifically focusing on lanosterol.

February 2, 2026EBioMedicine0 citationsOpen Access

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A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol

FFFranz FörsterLeipzig University KHKatrin HornLeipzig University JPJanne PottUniversity of Cambridge

Key Points

This research aims to identify genetic associations related to cholesterol synthesis intermediates, specifically focusing on lanosterol.
Conducted a genome-wide association meta-analysis.
Examined genetic variants associated with cholesterol synthesis intermediates.
Analyzed data across multiple populations.
Identified three significant genetic associations for lanosterol.
Findings suggest potential biomarkers for cholesterol metabolism.
Highlights the role of specific genetic pathways in lipid regulation.

Abstract

This investigation was primarily funded by the ministry for science and health of the Rhineland-Palatinate through the CoAGE graduate programme. A complete list of funding organisations is provided in the acknowledgements.

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A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol

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