Rh(I)-Catalyzed Dearomative Cycloisomerization of Furan-Tethered o -Alkynylphenyl Nitrones to Tropane-Containing Polycycles

Key Points

• To develop a synthetic method for creating dihydrofuran-fused tropane-containing polycycles using rhodium(I).
• Rhodium(I)-catalyzed reaction
• 6-exo-dig cycloaddition and internal redox processes
• Formation of azomethine ylides
• Dearomative [3 + 2] cycloaddition
• Successfully assembled dihydrofuran-fused polycycles
• Demonstrated the efficiency of the catalytic process
• Expanded the synthetic scope of tropane derivatives