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February 2, 2026Open Access

National Trends in Osteomyelitis-Related Mortality in the United States, 1999-2023

KSKrishna O. SanakaCleveland State University AWAndrew Wang SLSophie LockwoodGeorgia Department of Public Health

Key Points

The aim is to analyze trends in osteomyelitis-related mortality in the U.S. from 1999 to 2023.
Utilized CDC data for analysis
Calculated age-adjusted mortality rates
Identified trends specific to diabetes and trauma-related osteomyelitis
Overall annual percent change in mortality was 3.57%
Diabetes-related mortality increased at an APC of 4.07%
Trauma-related mortality rose significantly with an APC of 7.9%

Abstract

Abstract Using CDC data, we found rising age-adjusted mortality in the U.S. between 1999-2023, particularly diabetes- and trauma-related osteomyelitis. Overall osteomyelitis-related mortality annual percent change (APC) was 3.57%, and the diabetes- and trauma-associated osteomyelitis-related mortality APC were 4.07% and 7.9%, respectively. This highlights the need for improved osteomyelitis prevention and treatment.

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