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Demonstrates that targeting SF3B4 can suppress pancreatic cancer growth and migration, suggesting a new approach in treatment.
SF3B4 is a context-dependent splicing factor that functions as a tumor suppressor in PDAC by regulating autophagy and redox homeostasis. Targeting the SF3B4-autophagy-ROS axis may represent a promising strategy to suppress PDAC progression and overcome chemoresistance.
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Choi et al. (2026) studied this question.
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