Analysis investigates chromatin and transcriptional changes during neutrophil differentiation, indicating complex regulatory mechanisms.
Our work systematically investigates coordinated chromatin accessibility, TF binding, 3D genome-structure and transcriptional changes during neutrophil differentiation, especially at initialization. Our study highlights the sequential interplay between the initial changes of chromatin state, 3D genome organization and pioneer TF s such as CEBPA.
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Chen et al. (2026) studied this question.
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