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February 2, 2026Open Access

Method Development and Validation by HPLC (A Review)

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Authors

*W*1Dr. Ananthakrishnan, 2Dr. Jeyavelraman Kiruthika, 3Mr. P. Sriram, 4Mr. A. Raj Kumar, 5Mr. S. Jeevan Nithish, 6Gopal Dilip Wagh

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Overview

Review highlights optimization and validation of HPLC methods for drug analysis, suggesting improved practices for pharmaceutical applications.

Key Points

  • This review aims to summarize the essential processes involved in developing and validating HPLC methods for drug analysis.
  • Evaluating chromatographic factors such as sample preparation and mobile phase selection.
  • Focusing on the choice of column and detector type for method optimization.
  • Discussing compliance with Good Manufacturing Practice (GMP) during validation processes.
  • HPLC is identified as a highly efficient method for drug detection and quantification.
  • The review outlines the significance of method validation for ensuring accuracy and precision in pharmaceutical applications.
  • Highlights the necessity of a comprehensive validation policy for adherence to regulatory standards.

Cite This Study

*1Dr. Ananthakrishnan, 2Dr. Jeyavelraman Kiruthika, 3Mr. P. Sriram, 4Mr. A. Raj Kumar, 5Mr. S. Jeevan Nithish, 6Gopal Dilip Wagh (2026) studied this question.

synapsesocial.com/papers/6980fe7cc1c9540dea8108fehttps://doi.org/10.5281/zenodo.18439970
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