In vitro testing reveals AG-270 lacks cancer specificity in combination with recombinant methioninase, suggesting limited therapeutic use.
AG-270 showed lack of cancer specificity in combination with rMETase when tested on both cancer and normal cells. The present results contrast with numerous chemotherapy agents, which in combination with rMETase are synergistic on cancer cells but not on normal cells. The present findings suggest that MAT2A inhibition affects crucial metabolic pathways in normal as well as cancer cell types and thus AG-270 may not be suitable as a cancer-specific therapeutic strategy.
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Kim et al. (2026) studied this question.
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