Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies

January 30, 2026BMC Oral HealthOpen Access

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Key Points

To investigate the causal relationship between periodontitis and various systemic diseases using Mendelian randomization methods.
Conducted a systematic review of existing Mendelian randomization studies.
Analyzed genetic variants associated with periodontitis and their connection to systemic diseases.
Utilized the PROSPERO database for study registration and transparency.
Identified significant causal associations between periodontitis and several systemic diseases.
Demonstrated that genetic predisposition to periodontitis can increase the likelihood of developing systemic conditions.

This meta-analysis reveals causal links between periodontitis and systemic diseases, suggesting significant health implications.

The PROSPERO database lists this meta-analysis under the registration number CRD42024581585.

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Zhao et al. (2026) studied this question.

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