Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies

Key Points

• To investigate the causal relationship between periodontitis and various systemic diseases using Mendelian randomization methods.
• Conducted a systematic review of existing Mendelian randomization studies.
• Analyzed genetic variants associated with periodontitis and their connection to systemic diseases.
• Utilized the PROSPERO database for study registration and transparency.
• Identified significant causal associations between periodontitis and several systemic diseases.
• Demonstrated that genetic predisposition to periodontitis can increase the likelihood of developing systemic conditions.