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January 30, 2026BMC BiologyOpen Access

Horizontal transfer of post-translational modifiers brings evolutionary opportunity and challenges to a conserved translation factor

Tess E. Brewer Pavel Kielkowski Jingzhi Stritzel Florian Meier-Rosar Andreas Schlundt Jürgen Lassak

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Key Points

This research investigates how post-translational modifier (PTM) systems transferred via horizontal gene transfer (HGT) affect host proteins.
Analyzed the impact of different ef-p variants affected by off-target rhamnosylation.
Evaluated both the beneficial and detrimental effects of these modifications on EF-P function.
Different ef-p variants exhibited diverse responses to off-target rhamnosylation.
Some rhamnosylation reactions introduced novel, active PTMs, while others impaired EF-P function.
Complexity in gene integration and functional compatibility was emphasized.

Implication

Findings demonstrate varied effects on translation factors due to post-translational modifier transfer, highlighting evolutionary implications.

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Cite This Study

Brewer et al. (2026) studied this question.

synapsesocial.com/papers/6980fecbc1c9540dea811388 https://doi.org/10.1186/s12915-026-02531-9

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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4Sequence- and Base-Selective Modification of mRNA within and nearby Premature Termination Codon and Its Effect on the Translation in a Human Cell-Free Translation SystemOriginal Research · 2026
5Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and DiseasesReview · 2026 · 7 citations

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