Flow synthesis demonstrates effective sulfonate production using diazo esters and sulfonic acids under mild conditions.
The insertion reactions of α‐diazo esters to sulfonic acids have been efficiently run in flow with visible light irradiation, leading to the practical synthesis of aryl and alkyl sulfonates under mild room temperature without using any catalyst. Besides the sustainable reaction conditions, the current method displays attractiveness for the broad substrate tolerance and practical scale‐up synthesis.
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Hong et al. (2026) studied this question.
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