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February 2, 2026Food Safety and HealthOpen Access

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

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Authors

WLWanjun LiaoJLJia LiuYHYilian Huang

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Overview

Reveals a model of chronic kidney disease in mice, suggesting dietary adenine levels affect outcomes.

Key Points

  • To establish a reliable mouse model of chronic kidney disease (CKD) using different adenine diets.
  • Compared effects of four adenine diets (0.2% and 0.25%) in conventional and purified feed.
  • Measured serum urea nitrogen and creatinine to assess renal function.
  • Analyzed changes in gut microbiota and metabolic pathways.
  • All adenine diets increased serum urea nitrogen and creatinine levels.
  • The 0.2% adenine purified diet caused the most severe renal damage and led to hyperphosphatemia and hypercalcemia.
  • Gut microbiota showed significant reduction in Akkermansia and enrichment of Lactobacillus in the 0.2% adenine group.
  • Metabolic pathways involving phenylalanine, tyrosine, and tryptophan biosynthesis were strongly upregulated.

Cite This Study

Liao et al. (2026) studied this question.

synapsesocial.com/papers/6980ff37c1c9540dea81208bhttps://doi.org/10.1002/fsh3.70080
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