Radiologic phenotype-specific transcriptomic signatures in lung tissues from patients with Mycobacterium avium complex pulmonary disease

This study is the first to characterize transcriptomic differences between MAC-PD phenotypes using paired lung tissue samples. Although the identified transcriptomic markers require functional validation, their strong correlation with radiologic subtypes provides preliminary evidence supporting their potential diagnostic value. These findings lay the groundwork for precision diagnostics in MAC-PD and require further validation in larger patient cohorts and through functional assays.