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February 2, 2026BMC Microbiology0 citationsOpen Access

Fatty acids from Hermetia illucens larvae disrupt membrane integrity in colistin-resistant Acinetobacter baumannii

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HMH. B. MohamedMoscow Institute of Physics and TechnologySLS. V. LeonovMoscow Institute of Physics and TechnologyEMElena MarusichMoscow Institute of Physics and Technology

Key Points

  • To investigate the antibacterial effects of fatty acid extracts from Hermetia illucens larvae on colistin-resistant Acinetobacter baumannii.
  • Isolated fatty acid-enriched extracts from Hermetia illucens larvae.
  • Tested antibacterial activity against colistin-resistant Acinetobacter baumannii.
  • Analyzed membrane integrity disruption as a mechanism of action.
  • AWME3 extract showed potent antibacterial activity.
  • Disruption of membrane integrity was likely involved in the antibacterial mechanism.
  • Findings suggest insect-derived compounds could help combat multidrug-resistant pathogens.

Abstract

Fatty acid-enriched extracts from H. illucens larvae, particularly AWME3, exhibited potent antibacterial activity against colistin-resistant A. baumannii, likely through membrane-disruptive mechanisms. These findings highlight the potential of insect-derived bioactive compounds as sustainable alternatives for managing MDR pathogens.

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Cite This Study

Mohamed et al. (2026) studied this question.

synapsesocial.com/papers/6980ff49c1c9540dea8121e9https://doi.org/10.1186/s12866-026-04708-2
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