This work demonstrates a green method to convert chalcones into chlorohydrins using visible light and copper, suggesting a sustainable approach.
This work reports a green and sustainable method of chlorohydroxylation of chalcone derivatives via visible-light-induced copper catalysis under room temperature conditions to chemoselectively convert chalcones into the corresponding chlorohydrins. This approach enables the efficient conversion of various chalcone derivatives with electron-withdrawing and electron-donating groups. Preliminary mechanistic studies indicated that chlorine radical (Cl·) generated through the ligand-to-metal charge transfer process can promote the efficient construction of chlorohydrin structures.
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Shi et al. (2026) studied this question.
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