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February 2, 2026ThoraxOpen Access

Health trajectories of patients with amyotrophic lateral sclerosis before and after initiation of non-invasive ventilation: a French nationwide database analysis

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Authors

PTPierre TankéréEBE BernardÉHÉ. Herquelot

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Overview

Analysis Reveals Diverse Health Outcomes in ALS Patients Following Non-Invasive Ventilation Initiation, Suggesting Tailored Approaches.

Key Points

  • This research aims to examine disease trajectories and survival in ALS patients post-initiation of non-invasive ventilation (NIV).
  • Analyzed data from the French national health insurance database from 2015 to 2019 for ALS patients using NIV
  • Utilized K-clustering for health trajectory analysis
  • Included individuals aged 67 years, with a median time from diagnosis to NIV initiation of 10.8 months
  • Identified four distinct health trajectory clusters among ALS patients
  • Survival rates varied by cluster; Clusters B and C had longer survival post-NIV
  • Late NIV initiation linked to younger age, fewer comorbidities, and more physiotherapy sessions.

Cite This Study

Tankéré et al. (2026) studied this question.

synapsesocial.com/papers/6980ff49c1c9540dea81237fhttps://doi.org/10.1136/thorax-2025-223974
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