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lncRNA LUCAT1 Regulates DNA Damage Response in Glioma Stem Cells Under Hypoxia. | Synapse

February 2, 20260 citations

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lncRNA LUCAT1 Regulates DNA Damage Response in Glioma Stem Cells Under Hypoxia.

HHHaidong HuangCleveland Clinic HSHariti ShahCleveland Clinic HDHimanshu DashoraCleveland Clinic

Key Points

Investigate the role of LUCAT1 in regulating DNA damage response in glioma stem cells under hypoxic conditions.
Analyzed the expression levels of LUCAT1 in glioma stem cells under hypoxia.
Evaluated the impact of LUCAT1 on DNA damage response mechanisms.
Assessed the effects of LUCAT1 modulation on the efficacy of DDR inhibitors and radiotherapy.
LUCAT1 is found to be a significant regulator of DNA damage response in glioma stem cells.
Under hypoxia, LUCAT1 activity enhances DNA repair processes.
Modulating LUCAT1 can improve responses to DDR inhibitors and radiotherapy in glioma therapy.

Abstract

LUCAT1 is a critical DDR regulator in GSCs under hypoxia and a promising target to enhance the efficacy of DDR inhibitors and radiotherapy in GBM.

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Cite This Study

Huang et al. (Sat,) studied this question.

synapsesocial.com/papers/6980ffc6c1c9540dea81277a https://doi.org/https://doi.org/10.1093/neuonc/noag017