Abstract Marfan syndrome (MFS) is an autosomal dominant disorder characterized by multisystem connective tissue involvement, affecting the cardiovascular, skeletal, and ocular systems. Here, we report the case of a 54-year-old male with diabetes and hypertension who presented with dizziness and left-sided facial numbness. Clinical evaluation revealed classic Marfanoid features, and cardiovascular examination identified a diastolic murmur. Echocardiography and computed tomography angiography showed a large aortic root aneurysm (6.2 cm), a dilated ascending aorta (7 cm), significant aortic regurgitation, and severe left ventricular dilation. The patient underwent valve-sparing ascending aortic root replacement (David-V procedure). Postoperative echocardiography revealed preserved ventricular function, but the patient developed sustained ventricular tachycardia, requiring cardioversion. This case highlights the complexity of managing MFS with severe aortic involvement, emphasizing the need for early diagnosis, multidisciplinary care, and postoperative arrhythmia management to prevent life-threatening complications.
Raja et al. (2026) studied this question.