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Researchers demonstrate enhanced muscle paralysis using nerve stimulation during BoNT/A treatment in mice, suggesting potential for improved therapies.
We established an electrical and a magnetic nerve stimulation protocol combined with BoNT/A treatment in mice. Combination of i.m. BoNT/A injection with TENS or MS demonstrated an enhanced BoNT/A effect as compared to non-stimulated groups. Despite limitations of the magnetic stimulation method in the mouse our data revives the discussion of BoNT/A effect augmentation by stimulating the injected muscles' efferent nerves during the BoNT/A uptake phase.
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Honndorf et al. (2026) studied this question.
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