This research aims to examine the relationship between flortaucipir-PET, plasma p-tau217, and tau neuropathology in various neurodegenerative conditions.
Utilized flortaucipir-PET imaging to assess tau pathology in subjects.
Measured plasma levels of p-tau217 related to tau pathology.
Compared findings between Alzheimer disease and other neurodegenerative disorders.
Flortaucipir-PET showed high specificity for diagnosing Alzheimer disease.
Plasma p-tau217 had limited sensitivity for detecting early tau co-pathology outside of Alzheimer disease.
Abstract
Flortaucipir-PET and plasma p-tau217 both displayed strong specificity for primary AD neuropathologic diagnosis but limited sensitivity for early tau co-pathology in non-AD diagnoses.