A 30-year-old woman with acute-on-chronic lithium toxicity had a serum lithium level of 3.54 mmol/L, which prompted hemodialysis leading to clinical recovery.
Case Report (n=1)
No
Brain MRI can identify cytotoxic lesions of the corpus callosum as an early neuroimaging marker of lithium toxicity, facilitating prompt diagnosis and treatment with hemodialysis.
A 30-year-old woman with history of bipolar disorder presented to the emergency department with impaired consciousness and myoclonus following regular lithium treatment. Brain magnetic resonance imaging revealed a hyperintense lesion in the splenium of the corpus callosum, consistent with cytotoxic lesions of the corpus callosum (CLOCCs). Serum lithium levels were markedly elevated (3.54 mmol/L), and acute-on-chronic lithium toxicity was diagnosed. Hemodialysis and supportive care resulted in clinical and radiological recovery. This case highlights that CLOCCs may serve as important neuroimaging evidence of lithium toxicity and may support an early diagnosis and treatment, especially in patients with long-term lithium use.
Miura et al. (Thu,) conducted a case report in Acute-on-chronic lithium toxicity (n=1). Lithium carbonate vs. none was evaluated on Lithium serum concentration. A 30-year-old woman with acute-on-chronic lithium toxicity had a serum lithium level of 3.54 mmol/L, which prompted hemodialysis leading to clinical recovery.