Single-cell and Mendelian analyses identify shared features in head and neck neoplasms and aging, suggesting new therapeutic targets.
This study identified CD4_naive T cells down-regulation as a shared feature of HNN and aging and highlighted FHIT as potential molecular links. These findings may provide novel insights into the intersection of aging and tumorigenesis based on MR and single-cell analysis, offering potential targets for combined therapeutic strategies.
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Sun et al. (2026) studied this question.
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