Short-term metformin treatment reduces metabolic dysfunction in male rats exposed to neonatal overnutrition, indicating potential interventions.
These findings suggest that short-term metformin treatment in rats during puberty can mitigate adult metabolic dysfunction induced by neonatal overnutrition. However, this intervention in adulthood did not result in long-term metabolic changes, which confirms the DOHaD concept.
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Raposo et al. (2026) studied this question.
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