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Demonstrates chromatin context-dependent effects of CTCF on transcriptional regulation and cellular outcomes.
CTCF-dependent boundary integrity at the NOTCH1 locus tunes transcriptional output and cellular phenotypes in a chromatin context-dependent manner, supporting a model in which conserved 3D architecture constrains regulatory communication but yields distinct outcomes across cellular states.
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Cerecedo-Castillo et al. (2026) studied this question.
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