Key result
Higher uric acid-to-HDL-C ratio linked to higher abdominal aortic calcification scores, but not severe calcification.
Cross-Sectional (n=3,009)
Yes
Answers are grounded in this paper and cite their sources.
Observational study assesses the link between uric acid to HDL-C ratio and abdominal aortic calcification, suggesting its utility as a cardiovascular risk marker.
Previous studies have suggested associations between uric acid (UA), high-density lipoprotein cholesterol (HDL-C), and vascular calcification. The UA to HDL-C ratio (UHR) has recently emerged as a novel marker for cardiovascular risk. This study aimed to investigate the relationship between UHR and abdominal aortic calcification (AAC). Data were obtained from the 2013 to 2014 National Health and Nutrition Examination Survey and included participants aged 40 years and older with available data on UA, HDL-C, and AAC. Participants were categorized into quartiles based on UHR levels. AAC was evaluated using the Kauppila scoring system, with severe AAC defined as a score > 6. Weighted multivariable linear and logistic regression analyses were performed to assess the association between UHR, AAC scores, and severe AAC. Restricted cubic spline models were used to explore potential nonlinear relationships. A total of 3009 participants were included. Higher UHR was positively associated with AAC scores after full adjustment (β = 3.43, 95% confidence interval [CI]: 0.45–6.41, P = .024). Higher UHR was positively associated with AAC scores in all models, including the fully adjusted model (model 4: β = 3.43, 95% CI: 0.45–6.41, P = .024). Participants in the highest UHR quartile (Q4) had AAC scores ~0.70 units higher than those in the lowest quartile (Q1). With respect to severe AAC, higher UHR was significantly associated with increased risk in unadjusted (model 1: odds ratio = 17.93, 95% CI: 2.04–157.42, P = .009) and partially adjusted (model 2: odds ratio = 24.74, 95% CI: 1.94–315.34, P = .013) models, but not after full adjustment (model 3: P = .185; model 4: P = .365). Restricted cubic spline analysis revealed a linear relationship between UHR and AAC scores ( P for overall association = 0.02, P for nonlinearity = 0.741). Elevated UHR was independently associated with higher AAC scores but not with severe AAC adjustment for potential confounders. These findings suggest that UHR may serve as a useful marker for assessing the severity of AAC in adults aged 40 years and older.
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Guo et al. (2026) conducted a cross-sectional in Abdominal aortic calcification (AAC) (n=3,009). Uric acid to HDL-cholesterol ratio (UHR) vs. Lowest UHR quartile (Q1, <0.08) / continuous per-unit increase was evaluated on Abdominal aortic calcification (AAC) score (Kauppila score 0-24) (β = 3.43, 95% CI 0.45–6.41, p=0.024). Higher uric acid-to-HDL-C ratio was independently associated with higher abdominal aortic calcification scores (β = 3.43, 95% CI 0.45–6.41, P = 0.024), though not with severe calcification.
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