Three‐in‐One Multifunctional Metal–Organic Gel‐Encapsulated Microneedles for Programmed Treatment of Infected Wounds

Refractory wounds caused by multidrug‐resistant (MDR) bacterial infections are characterized by biofilm formation, persistent inflammation, and impaired angiogenesis, requiring stage‐specific therapeutic strategies. Herein, we propose a three‐in‐one multifunctional metal–organic gel‐encapsulated microneedle (Cu‐MOG MN) with integrated antibacterial, anti‐inflammatory, and pro‐angiogenic capabilities for the programmed treatment of infected wound. Cu‐MOG is constructed via facile coordination and self‐assembly between naturally antioxidant phytic acid (PA) and essential trace element copper, and exhibits well‐defined pH‐responsive multienzyme activities. During the early stage of bacterial infection, Cu‐MOG activates superoxide dismutase–peroxidase (SOD–POD) cascade to generate localized reactive oxygen species (ROS), enabling efficient bacterial eradication and biofilm disruption. As the wound microenvironment transitions to neutral inflammatory conditions, the catalytic profile shifts to SOD–glutathione peroxidase (GPx) activity, scavenging excess ROS and alleviating oxidative stress. In addition, Cu‐MOG exerts potent immunomodulatory effects by promoting macrophage polarization toward the pro‐regenerative M2 phenotype, while simultaneously enhancing collagen deposition, angiogenesis, and cell migration to accelerate wound healing. Collectively, the Cu‐MOG MN system achieves a comprehensive therapeutic cascade through synergistic deep tissue penetration, pH‐responsive antibacterial/anti‐inflammatory actions, and pro‐regenerative stimulation of collagen deposition/angiogenesis, showing great potential for precise, dynamic and adaptive treatment of refractory wounds.