Punicalagin is the key pomegranate polyphenol inhibiting gut microbial trimethylamine (TMA) production from l -carnitine in an in vitro human colon model

J. E. Haarhuis; M. I. Gamal El-Din; Dimitra Lamprinaki; P. A. Kroon

doi:10.1039/d5fo04781a

January 1, 2026Food & FunctionOpen Access

Punicalagin is the key pomegranate polyphenol inhibiting gut microbial trimethylamine (TMA) production from l -carnitine in an in vitro human colon model

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Key Points

The aim is to investigate how punicalagin inhibits TMA production from l-carnitine by gut microbiota.
In vitro human colon model used.
Measured the effect of punicalagin on TMA production.
Utilized microbiota capable of converting l-carnitine to TMA.
Punicalagin significantly reduces TMA production from l-carnitine.
Highlighting a potential dietary intervention to lower proatherogenic TMA levels.

Implication

In vitro analysis reveals punicalagin's effect on TMA production from l-carnitine by gut microbiota, suggesting dietary benefits.

Abstract

Punicalagin is the single pomegranate polyphenol inhibiting the production of proatherogenic trimethylamine (TMA) from l -carnitine in vitro . Dietary l -carnitine is converted by gut microbiota to TMA. Created in BioRender.

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Cite This Study

Haarhuis et al. (2026) studied this question.

synapsesocial.com/papers/698433c8f1d9ada3c1fb13a9 https://doi.org/10.1039/d5fo04781a

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Punicalagin is the key pomegranate polyphenol inhibiting gut microbial trimethylamine (TMA) production from l -carnitine in an in vitro human colon model

Key Points

Implication

Abstract

Discussion

Cite This Study

Punicalagin is the key pomegranate polyphenol inhibiting gut microbial trimethylamine (TMA) production from l -carnitine in an in vitro human colon model

Key Points

Implication

Abstract

Discussion

Cite This Study

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