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February 5, 20260 citations

Structural And Evolutionary Analysis Of Zika Virus NS5 Protein

Structural And Evolutionary Analysis of Zika Virus NS5 Protein

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Authors

NSN SujethaRKRohini KMNMohan N

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Overview

Bioinformatics reveals structural insights of Zika virus NS5 protein, suggesting targets for antiviral therapies.

Key Points

  • The study aims to examine the structure-function relationship of the Zika virus NS5 protein using bioinformatics and simulations.
  • Utilized multiple sequence alignment and evolutionary tree construction
  • Predicted secondary structures including alpha helices and beta strands
  • Refined and validated the three-dimensional structure of NS5
  • Conducted molecular dynamics simulations to assess protein flexibility and stability
  • Predicted significant secondary structures in NS5 protein
  • Three-dimensional structure validation confirmed structural integrity
  • Molecular dynamics revealed insights into protein flexibility and stability
  • Established links between structural features and functional roles in the viral life cycle

Cite This Study

Sujetha et al. (2025) studied this question.

synapsesocial.com/papers/69843405f1d9ada3c1fb1aa2https://doi.org/10.1051/bioconf/202517202006/pdf
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