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Reveals the resistance landscape to ALK inhibitors in ALK-driven cancers through a functional atlas of variants, indicating potential strategies for treatment.
This study provides a comprehensive functional atlas of ALK tyrosine kinase domain variants under TKI selection, offering a valuable experimental framework for interpreting resistance-associated variants. Although derived from in vitro models and therefore context dependent, this resource complements existing clinical and genomic knowledge and may aid in the functional interpretation of ALK variants observed in ALK-driven cancers.
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Oh et al. (2026) studied this question.
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