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February 5, 2026Journal of Orthopaedic Surgery and Research2 citationsOpen Access

Leukocyte-rich versus leukocyte-poor platelet-rich plasma and hyaluronic acid for knee osteoarthritis: a systematic review and network meta-analysis

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BXBing XuXHXinyun HuangXSXiaojie Su

Key Points

  • This research aims to compare the efficacy and safety of leukocyte-rich platelet-rich plasma (L-PRP) and leukocyte-poor platelet-rich plasma (LP-PRP) for treating knee osteoarthritis (KOA).
  • Conducted a systematic review and network meta-analysis
  • Compared intra-articular injections of L-PRP and LP-PRP with hyaluronic acid (HA)
  • Evaluated functional improvement and pain relief outcomes
  • Both L-PRP and LP-PRP provide significant functional improvement and pain relief in KOA
  • L-PRP shows superior efficacy compared to HA
  • Trends suggest LP-PRP may have a better safety profile, but data is inconclusive

Abstract

Intra-articular PRP provides clinically significant functional improvement and pain relief for patients with KOA, with an efficacy superior to that of HA. Both L-PRP and LP-PRP are effective treatment options with comparable efficacy based on current evidence. Although qualitative trends suggest a potentially better safety profile for LP-PRP, robust data are lacking. Therefore, there is insufficient evidence to recommend one PRP formulation over the other.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69843433f1d9ada3c1fb20e8https://doi.org/10.1186/s13018-026-06689-4
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