Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway

Siyun Lei; Jing Zhou; Xiangyu Hu; Jinpeng Xie; Lihong Wang; Ting Kou; Lei Xu; Jue Wang; Yang Cheng; Shuaifei Zhao; Ting Zhang; Dandan Lu; Ying Chen; Yuxiu Ying; Xiaoshuang Xin; Xu Xu; Yusu Zhang; Jun Wang; Chenyu Qiu; Gu Cheng; Qiqi Lyu; Minghao Lin; Yihuai Pan; Tong Cao

doi:10.1186/s13287-026-04912-x

Key Points

The aim is to explore how endothelial cell-derived apoptotic vesicles influence endothelial progenitor cell differentiation and angiogenesis.
Investigated the effects of endothelial cell-derived apoptotic vesicles on endothelial progenitor cells in vitro and in vivo.
Analyzed the role of mir-30a-5p in the signaling mechanism.
Examined the activation of the EGFR/PI3K/AKT/VEGF pathway.
Apoptotic vesicles significantly promote endothelial progenitor cell differentiation and angiogenesis.
Presence of miR-30a-5p inhibits PML, leading to pathway activation.
The activation of the EGFR/PI3K/AKT/VEGF signaling pathway is crucial for promoting these effects.

Implication

This research demonstrates how apoptotic vesicles promote progenitor cell differentiation and angiogenesis, suggesting new therapeutic strategies.

Abstract

EC-derived Apo-EVs demonstrated excellent capacity to promote EPCs differentiation and angiogenesis both in vitro and in vivo, the mechanism is associated with miR-30a-5p within the vesicles inhibiting PML and activating the EGFR/PI3K/AKT/VEGF signaling pathway. This finding provides a new perspective for revealing the role of EC-derived Apo-EVs in tissue repair and offers potential strategies for the treatment of related diseases.

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Cite This Study

Lei et al. (2026) studied this question.

synapsesocial.com/papers/698434b4f1d9ada3c1fb3201 https://doi.org/10.1186/s13287-026-04912-x

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Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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