Profound Effect of Light on Cysts in X-Linked Retinoschisis

Initial findings suggested a diurnal rhythm in cyst size but reversed light cycle experiments showed that light exposure-not time of day-drives retinal changes in Rs1-KO mice. RS1-deficient retinas are vulnerable to darkness, whereas light exposure preserves retinal structure and function. To ensure valid OCT and ERG comparisons in XLRS, measurements should be time- and lighting-stamped. Dark-adapted conditions may best reveal treatment effects. Controlled light exposure may be a therapeutic option for patients with XLRS.