Key result
Clopidogrel monotherapy reduces MACCE vs aspirin in CAD without increasing major bleeding.
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May support clopidogrel over aspirin monotherapy in CAD; challenges aspirin-first guidelines and extends RCT evidence on antiplatelet choice.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
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Michelle D. Kelsey (2026) studied this question. Clopidogrel monotherapy reduces MACCE without increasing major bleeding compared to aspirin in patients with coronary artery disease.
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