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January 1, 2026The Analyst

A dual-modal ¹⁹ F MRI / ¹⁸ F PET approach using sultones derived chemical tags

Amaury Guillou Nicolas Joudiou Alice Fortin Fabienne Gourand Lionel Mignion Bénédicte F. Jordan Jun‐An Ma Cécile Perrio

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Key Points

The study aims to improve imaging probe design by enhancing biocompatibility and hydrophilicity for 19F MRI.
Developed sultone-derived chemical tags for imaging probes
Evaluated the hydrophilicity and biocompatibility of the probes
Utilized dual-modal 19F MRI and 18F PET techniques for imaging
Enhanced biocompatibility of imaging agents was achieved
Hydrophilicity improved, allowing for better water solubility
Successful dual-modal imaging demonstrated efficacy for biological applications

Implication

This research demonstrates a new imaging approach using 19F MRI and 18F PET in water-soluble probes, indicating enhanced biocompatibility.

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Cite This Study

Guillou et al. (2026) studied this question.

synapsesocial.com/papers/69843564f1d9ada3c1fb42b0 https://doi.org/10.1039/d5an01102g

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A Multifunctional Contrast Agent for <sup>19</sup>F-Based Magnetic Resonance ImagingOriginal Research · 2022 · 5 citations
2A Macrocyclic Hybrid PET/MRI Probe for Quantitative Perfusion Imaging <i>In Vivo</i>2024 · 9 citations
3UV-Activated Zwitterionic Fluorine-Containing Hybrid Probe for Dual-Modal <b> <sup>19</sup> </b> F/ <b> <sup>1</sup> </b> H MRIOriginal Research · 2026
4Superfluorinated, Highly Water-Soluble Polyphosphazenes as Potential 19F Magnetic Resonance Imaging (MRI) Contrast Agents2024 · 8 citations
5<sup><b>18</b></sup>F-Fluorination of Nitroimidazolyl-Containing Sultone: A Direct Access to a Highly Hydrophilic Radiotracer for High-Performance Positron Emission Tomography Imaging of Hypoxia2024 · 4 citations

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A Novel Arene Trifluoromethyl-Based <sup>18</sup>F-Labeling Strategy for Enhanced Biomolecular Tracer Development in PET Imaging2025
3,5-Bis(2-hexafluoro-isopropoxyl)phenyl: A Super-Fluorinated Moiety with Favorable Water-Solubility and Modifiability for <sup>19</sup> F Magnetic Resonance Imaging2026
Targeted Dual-Modality Imaging of Inflammation Using <sup>18</sup> F-Radiolabeled Iron Oxide Microparticles2025

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