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February 5, 2026Health Science Reports1 citationsOpen Access

Association Between Serum Vitamin D Levels and Mortality in Children Receiving Chronic Dialysis: A Retrospective Cohort Study

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SKSima Shamshiri KhameneIKIzat Mohammad KhawajahMMMastaneh Moghtaderi

Key Points

  • The study aims to investigate the relationship between serum vitamin D levels and mortality rates in children undergoing chronic dialysis.
  • Conducted a retrospective cohort analysis of 53 pediatric patients receiving dialysis.
  • Assessed serum vitamin D levels and tracked mortality outcomes over a two-year period.
  • Analyzed correlations between vitamin D levels and various biochemical markers.
  • 26.41% of patients died during the study.
  • Higher mortality rates were linked to severe vitamin D deficiency, with a hazard ratio of 3.2 for levels below 15 ng/mL.
  • No deaths were recorded in patients with sufficient vitamin D levels above 30 ng/mL.

Abstract

ABSTRACT Background Vitamin D deficiency is highly prevalent among children on regular dialysis, affecting approximately 90% of patients. This deficiency (serum 25‐hydroxyvitamin D 30 ng/mL) recorded no deaths. Additionally, 11.32% developed skeletal disorders, including two cases of spinal fracture. Vitamin D levels showed significant positive correlations with calcium ( r = 0.6) and years under dialysis ( r = 0.52) ( p > 0.05). Associations were found between vitamin D levels and phosphorus, PTH, and mortality rates. However, no significant relationships were observed with dialysis frequency, age, weight, gender, underlying disease, dialysis type, or hypertension. Conclusion In conclusion, children with end‐stage renal disease undergoing dialysis face increased risks of vitamin D deficiency due to impaired kidney function. This deficiency significantly impacts survival rates and contributes to poor outcomes. Regular monitoring and management of vitamin D levels are crucial for improving survival in pediatric dialysis patients.

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Cite This Study

Khamene et al. (2026) studied this question.

synapsesocial.com/papers/6984358ff1d9ada3c1fb4723https://doi.org/10.1002/hsr2.71804
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