This research aims to investigate the effects of ginger supplementation on autistic behaviors in a prenatal valproic acid-induced mouse model by targeting AKT/GSK3β signaling.
Used a mouse model exposed to prenatal valproic acid (VPA) to mimic autism spectrum disorder (ASD) symptoms.
Administered ginger extract (GE) to assess its effects on behavior and signaling pathways.
Conducted network pharmacology analyses and molecular docking to explore the interactions at a molecular level.
Ginger supplementation improved autistic behaviors in the VPA-exposed mice.
Modulation of AKT/GSK3β signaling pathways was observed following ginger treatment.
Findings underscore the role of ginger in potentially mitigating symptoms of autism.
Abstract
Schematic diagram showing the effects of GE in a VPA-induced ASD mouse model through an integrated strategy encompassing network pharmacology, molecular docking analysis, and in vivo experimental validation.