Stimuli-responsive hydrogels are an emerging class of smart materials with immense potential across biomedical engineering, soft robotics, environmental systems, and advanced manufacturing. In this review, we present an in-depth exploration of their material design, classification, fabrication strategies, and real-world applications. We examine how a wide range of external stimuli—such as temperature, pH, moisture, ions, electricity, magnetism, redox conditions, and light—interact with polymer composition and crosslinking chemistry to shape the responsive behavior of hydrogels. Special attention is given to the growing field of 4D printing, where time-dependent shape and property changes enable dynamic, programmable systems. Unlike existing reviews that often treat materials, stimuli, or applications in isolation, this work introduces a multidimensional comparative framework that connects stimulus-response behavior with fabrication techniques and end-use domains. We also highlight key challenges that limit practical deployment—including mechanical fragility, slow actuation, and scale-up difficulties—and outline engineering solutions such as hybrid material design, anisotropic structuring, and multi-stimuli integration. Our aim is to offer a forward-looking perspective that bridges material innovation with functional design, serving as a resource for researchers and engineers working to develop next-generation adaptive systems.
Siddique et al. (2026) studied this question.