¹²⁴ I-radiolabeled Exosome-Based Treatment Platform for Enhanced Boron Neutron Capture Therapy: Precise Delivery and Real-Time PET Tracking of Boron

Ziteng Chen; Zhijie Wang; Mingxin Yang; Ruyu Yan; Linwen Lv; Yanan Chang; Kui Chen; Wenjiang Yang; Hui Yuan; Xiangxi Meng; Lingbo Zhu; Zhi Yang; Gengmei Xing; Juan Li

doi:10.1039/d5nr04823k

January 1, 2026Nanoscale

¹²⁴ I-radiolabeled Exosome-Based Treatment Platform for Enhanced Boron Neutron Capture Therapy: Precise Delivery and Real-Time PET Tracking of Boron

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Key Points

The aim is to develop an exosome-based platform for the targeted delivery of boron in BNCT, improving treatment precision.
Developed a radiolabeled exosome-based system for boron delivery.
Utilized positron emission tomography (PET) for real-time tracking of boron distribution in tumors.
Conducted evaluations of boron accumulation and its effects during neutron irradiation.
The exosome platform showed significantly increased boron accumulation in tumor cells compared to traditional methods.
Real-time PET tracking allowed for precise monitoring of boron distribution during therapy.
The treatment enhanced the effectiveness of BNCT by ensuring better synchronization with neutron irradiation.

Implication

Demonstrates enhanced boron delivery and real-time tracking in tumors, suggesting improved BNCT efficacy.

Abstract

Boron neutron capture therapy (BNCT) is a promising targeted radiotherapy modality, whose efficacy critically depends on the precise spatiotemporal synchronization of sufficient boron accumulation in tumor cells with neutron irradiation....

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/698435b9f1d9ada3c1fb4e17 https://doi.org/10.1039/d5nr04823k

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¹²⁴ I-radiolabeled Exosome-Based Treatment Platform for Enhanced Boron Neutron Capture Therapy: Precise Delivery and Real-Time PET Tracking of Boron

Key Points

Implication

Abstract

Discussion

Cite This Study

¹²⁴ I-radiolabeled Exosome-Based Treatment Platform for Enhanced Boron Neutron Capture Therapy: Precise Delivery and Real-Time PET Tracking of Boron

Key Points

Implication

Abstract

Discussion

Cite This Study

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