Stereodivergent Access to Aliphatic Nitro Compounds Bearing Multi‐Contiguous Stereocenters via Sequential Catalysis

Herein, we report a highly efficient synthesis of aliphatic nitro compounds bearing multi‐contiguous stereocenters in good yields (up to 72%) with excellent diastereo‐ and enantio‐selectivities (up to 12:1 dr, and >99% ee) by combining copper‐catalyzed asymmetric conjugate addition of dialkylzinc reagents to nitroalkenes with iridium‐catalyzed asymmetric allylic substitution reaction. Stereodivergent construction of nonadjacent stereocenters (1,3‐positions) has been achieved by combining two chiral catalysts with different enantiomers. By first introducing a chiral center at the β‐position of the nitro group, highly diastereoselective control has been achieved in iridium‐catalyzed allylic substitution reaction of prochiral nitro compounds.